Soluble B-cell Maturation Antigen in Multiple Myeloma and Correlation With Response to Therapy.

ABSTRACT:

Aim

B-cell maturation antigen (BCMA) is a nontyrosine kinase receptor expressed during plasma cell differentiation. Binding of ligands such as APRIL and BAFF to BCMA on malignant plasma cells leads to proliferation of tumor cells and plays an important role in the pathogenesis of multiple myeloma. Recent studies have explored the role of serum-soluble BCMA (sBCMA) in assessing tumor load as well as monitoring of response. In this study, we aimed to detect serum sBCMA levels in newly diagnosed multiple myeloma patients as well as monitor the levels at follow-up to correlate with response to therapy.

Methods

This was a prospective, longitudinal study conducted between March 2023 and July 2024. We documented the routine disease characteristics along with sBCMA levels at baselin

SUBMITTER: Saha S 

PROVIDER: S-EPMC12539665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature