Amino-Functionalized Carbon Nanodots Inhibit Biofilms and Infections in a Burn Wound Model, Both Caused by <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Candida albicans</i>, and <i>Aspergillus brasiliensis</i>.

ABSTRACT: Burn wounds are debilitating injuries that contribute significantly to global morbidity and mortality. The disruption of skin integrity elevates the risk of infection, which can impede healing and potentially lead to sepsis. Furthermore, antibiotic resistance, primarily driven by biofilm formation, poses a major challenge to effective treatment. This study is aimed at evaluating the potential of positively charged carbon dots (CDs) in inhibiting biofilm formation, with possible applications in wound care. Specifically, carbon nanodots (CDs-NH₂) were tested in vitro against both planktonic cells and biofilms formed by a range of pathogens, including the Gram-positive bacterium Staphylococcus aureus, the Gram-negative bacterium Escherichia coli, the yeast Candida

SUBMITTER: Giusti V 

PROVIDER: S-EPMC12539990 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature