Probing mitochondrial peroxynitrite biogenesis by a N-morpholinoarylimine-based iridium(III) complex in drug-induced liver cells.

ABSTRACT: Peroxynitrite (ONOO^-), a strong oxidizing agent, has an important function in the pathogenesis of various diseases, including cardiovascular, inflammatory and neurodegenerative diseases. Specifically, mitochondrial ONOO^- exacerbates liver injury by driving oxidative/nitrative stress and mitochondrial dysfunction, ultimately triggering dual apoptotic-necrotic hepatocyte death pathways. ONOO^- and its functions have been widely studied by fluorescence imaging probes, owing to their strong sensitivity, non-invasiveness, and real-time ability. However, existing probes are heavily constrained by interference from other reactive species. Herein, we describe a luminescent iridium(III) complex (1) with an N-morpholinoarylimine moiety as the recognition site for ONOO

SUBMITTER: Kong L 

PROVIDER: S-EPMC12540033 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature