Profiling the composition of resistome and bacteriome in the upper respiratory tract of domestic cats with respiratory signs in China.

ABSTRACT: Aim: Domestic cats, among the most popular pets globally, may harbor antimicrobial resistance genes (ARGs) and zoonotic pathogens that impact human health. This study aims to investigate the resistome and bacteriome composition in the upper respiratory tract of domestic cats with respiratory signs in China. Methods: We performed metagenomic sequencing on 1,454 oropharyngeal-nasal swabs from cats with respiratory signs across diverse living conditions in 22 Chinese provinces. Resistome and bacteriome profiles were analyzed using these sequencing data. Results: We characterized the resistome and bacteriome in the upper respiratory tract of cats, identifying a wide range of ARGs - including those conferring resistance to last-resort antibiotics {e.g., carbapenems (bla<

SUBMITTER: Li Q 

PROVIDER: S-EPMC12540054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature