Bioinformatics identification of mitochondria and macrophage polarization-related genes in COPD and their potential mechanisms.

ABSTRACT:

Introduction

This study investigated key genes associated with both chronic obstructive pulmonary disease (COPD) and macrophage polarization or mitochondrial dysfunction, and explored their underlying mechanisms through bioinformatics analysis.

Methods

Data from GSE151052, GSE106986, and GSE171541 were utilized. Critical module genes linked to mitochondria-related genes (MRGs) and macrophage polarization-related genes (MPRGs) were identified via co-expression networks. Biomarkers for COPD were then screened using differential expression analysis, machine learning, and receiver operating characteristic (ROC) curves. A nomogram was developed to assess COPD risk. Additionally, immune infiltration, molecular regulation, and drug prediction analyses were conducted. Single-

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12540082 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature