Posterior communicating artery vasospasm impairs cerebral pulsatility in an experimental subarachnoid hemorrhage model.

ABSTRACT:

Background

Subarachnoid hemorrhage (SAH) commonly causes cerebral vasospasm and delayed ischemia. Spasm of the posterior communicating artery (PCoA) can disrupt cerebral hemodynamics. We assessed its effect on cerebral pulsatility in a rabbit SAH model, focusing on intracranial pressure pulse amplitude as an early, sensitive marker of vasospasm-driven change, whereas global CBF or neurological outcomes generally require larger or longer studies.

Methods

Rabbits were randomly assigned to three groups: control (no injection), sham-controlled (saline injection), and SAH (0.75 mL autologous blood injection into the basal subarachnoid space near the PCoA under anesthesia). Heart rate and cerebral pulsation amplitude (measured via intracranial pressure transducer) were recorded on

SUBMITTER: Daltaban IS 

PROVIDER: S-EPMC12540087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature