Novel Immune biomarkers for the early stratification of oligoarthritis patients at risk of developing polyarticular extension.

ABSTRACT:

Introduction

Oligoarthritis, the most common form of Juvenile Idiopathic Arthritis in Western countries and a leading cause of disability, exhibits a variable clinical course. Early identification of children at risk of polyarticular extension is critical for guiding targeted therapy, but requires new biomarkers. This study aimed at profiling T cell and monocyte/macrophage (MM) subset composition and activation/maturation state combined with extracellular vesicle (EV) surface markers in synovial fluid (SF) and peripheral blood (PB) from new-onset Oligoarthritis patients to prospectively evaluate their correlation with clinical course over a two-year follow-up period and identify potential prognostic biomarkers.

Methods

SF and PB samples were collected from 42 untreated patie

SUBMITTER: Raggi F 

PROVIDER: S-EPMC12540104 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature