A novel role for Hsc70-4 in blood cell differentiation in <i>Drosophila</i>.

ABSTRACT: The Drosophila lymph gland serves as an excellent model for studying blood cell development, closely mirroring the key components of mammalian hematopoietic niches: blood cell progenitors, mature blood cells, and niche cells that secrete signals to regulate progenitor maintenance. In the Drosophila larva, two primary types of mature hemocytes exist: macrophage-like plasmatocytes and platelet-like crystal cells. In cases of immune challenge or neoplastic conditions, a third type of hemocyte, the lamellocyte, appears to encapsulate large invaders that plasmatocytes cannot phagocytose. Importantly, the spontaneous appearance of lamellocytes in unchallenged larvae indicates defects in progenitor maintenance or blood cell fate regulation. In this study, we uncover a novel role for

SUBMITTER: Kharrat B 

PROVIDER: S-EPMC12540110 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature