Diffusion tensor imaging along the perivascular space may reveal potential pathological mechanisms underlying disease progression in primary open-angle glaucoma patients.

ABSTRACT:

Purpose

This study investigates glymphatic system dysfunction in primary open-angle glaucoma (POAG) patients and explores its potential role in the progressive decline of visual function associated with the disease.

Methods

This prospective study compared 47 primary open-angle glaucoma (POAG) patients and 50 healthy controls (HCs) using multimodal MRI, including DTI, T1/T2-weighted imaging, and resting-state fMRI. Group differences in brain morphometry, spontaneous activity, perivascular space (PVS) volume, and DTI-ALPS index were analyzed, with regression and mediation models exploring their relationships. Ocular parameters (intraocular pressure, RNFL thickness, cup-to-disc ratio, visual field) were correlated with fMRI findings, particularly PVS and ALPS metrics.

Result

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12540159 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature