<i>Barnesiella intestinihominis</i> improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation.

ABSTRACT:

Introduction

Impaired glucose regulation (IGR) is a prediabetic state closely associated with gut microbiota dysbiosis. Our previous metagenomic analysis identified a significant deficiency of Barnesiella intestinihominis (B. intestinihominis) in IGR patients (p < 0.01). The present study was therefore designed to investigate the therapeutic potential of B. intestinihominis supplementation in a high-fat diet (HFD)-induced IGR mouse model and to explore its potential mechanisms of action.

Methods

A mouse model of IGR was established by HFD. The treatment group received a daily supplementation of live B. intestinihominis (1×10⁸ CFU) for 5 weeks. Gut microbiota composition was analyzed. Colonic expression levels of tight junction pr

SUBMITTER: Liu X 

PROVIDER: S-EPMC12540160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature