A novel circulating miRNA panel for early differential diagnosis of pulmonary tuberculosis from lung cancer with similar radiographic presentations.

ABSTRACT: This study aimed to establish a novel diagnostic approach based on a circulating microRNA (miRNA) panel to reliably distinguish pulmonary tuberculosis (PTB) from lung cancer (LC), particularly in patients presenting with overlapping radiographic features. A total of 592 participants were enrolled. In the discovery phase, miRNA expression profiles from 284 individuals, including PTB patients, LC patients, and healthy controls (HC), were analyzed to screen potential biomarkers. Candidate miRNAs were subsequently validated in an independent cohort of 308 plasma samples. The analysis revealed significant upregulation of hsa-miR-342-3p, hsa-miR-199a-3p, and hsa-miR-199b-3p in PTB compared with LC. A diagnostic panel incorporating these three miRNAs demonstrated robust performance, achieving an

SUBMITTER: Liu X 

PROVIDER: S-EPMC12540171 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature