In vivo gastrin releasing peptide receptor expression in SDH deficient wild-type gastrointestinal stromal tumours (GIST): potential for theranostic applications.

ABSTRACT:

Background

Succinate dehydrogenase (SDH) deficient wild-type Gastrointestinal Stromal Tumours (wtGIST) are a rare GIST subtype with limited treatment options. Gallium-68 labelled Gastrin Releasing Peptide Receptor (GRPR) antagonist NeoB has shown promise in PET imaging for multiple primary malignancies. This investigation sought to assess the biodistribution of [⁶⁸Ga]NeoB via PET/CT imaging in metastatic wtGIST patients and aimed to evaluate GRPR expression in lesions to determine the ligand's potential for patient selection in future therapeutic trials.

Results

Twelve patients with histologically confirmed metastatic wtGIST were enrolled. [⁶⁸Ga]NeoB PET/CT imaging was conducted for lesion segmentation and analysis of uptake characteristics. 8 of 12 (66

SUBMITTER: Hulse DGE 

PROVIDER: S-EPMC12540235 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature