Identification and validation of prognostic genes for lung adenocarcinoma prognosis based on PANoptosis-related genes.

ABSTRACT:

Background

PANoptosis, a newly identified form of cell death, has been linked to both the destruction of cancer cells and the regulation of antitumor immunity. This study aimed to establish a PANoptosis-related signature associated with lung adenocarcinoma (LUAD), highlighting its role in LUAD pathogenesis.

Methods

Transcriptome data from the TCGA-LUAD dataset were analyzed to identify PANoptosis-related differentially expressed genes (PANR-DEGs). A LUAD gene signature was developed using Cox regression and LASSO analyses. The study also evaluated somatic mutations, the immune microenvironment, and immunotherapy potential across two risk groups. Additionally, prognostic gene expression was validated clinically by reverse transcription-quantitative PCR (RT-qPCR).

Results</

SUBMITTER: Song GQ 

PROVIDER: S-EPMC12540239 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature