Developmental regulation of long-range neuroblast migration by Eph/ephrin signaling.

ABSTRACT: In the developing mouse anterior forebrain, the rostral migratory stream (RMS) supports continued proliferation and efficient transportation of large quantities of neuroblasts from the ventricular-subventricular (V-SVZ) stem cell niche to the olfactory bulb (OB). Astrocytes aid this migration by providing a glial network through which chains of fasciculated neuroblasts move. The largest receptor tyrosine kinase family, Eph receptors, and their ephrin ligands have been implicated in controlling neuroblast migration and astrocyte organization within this pathway. However, a clear understanding of the regulatory mechanisms underlying Eph/ephrin signaling remains elusive due, in part, to the complexity of heterogeneous expression patterns in both neuroblasts and astrocytes, as well as the cyto

SUBMITTER: Yeroshenko D 

PROVIDER: S-EPMC12540379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature