A novel capsular operon and potentially conjugative plasmids in extensively drug-resistant urogenital <i>Haemophilus parainfluenzae</i>.

ABSTRACT:

Introduction

Haemophilus parainfluenzae is an opportunistic pathogen increasingly associated with urogenital infections and multidrug resistance. While polysaccharide capsules are known virulence factors in H. influenzae, their role in H. parainfluenzae remains poorly understood. This study aimed to characterize a new capsular operon identified in H. parainfluenzae and analyze the antimicrobial resistance profile of strains carrying this operon to provide insights into their pathogenic potential.

Methods

Two clinical isolates from genital ulcers were subjected to whole-genome sequencing. The capsular operon was identified and characterized using comparative genomics. Antimicrobial susceptibility was determined using broth microdilution, and the re

SUBMITTER: Saiz-Escobedo L 

PROVIDER: S-EPMC12540396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature