The association of the triglyceride-glucose index and its changes with 5-year all-cause mortality in patients with depression.

ABSTRACT:

Background

Depression, as the primary contributor to the global disease burden caused by mental disorders, necessitates the urgent discovery of new biomarkers to predict patient prognosis, thereby facilitating early treatment. The triglyceride glucose index (TyG), which has a close relationship with insulin resistance (IR), systemic inflammation, and other factors, could potentially serve as a valuable biomarker for determining depression severity. However, the association of the TyG index and its changes with the long-term prognosis of depression remains unexplored. This article aims to evaluate whether the levels and changes in the TyG index can predict long-term mortality in patients suffering from depression.

Methods

A retrospective cohort study was conducted based on th

SUBMITTER: Cui XJ 

PROVIDER: S-EPMC12540422 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature