Postpartum depression-associated localized neural dysfunction: a voxel-wise meta-analysis of amplitude and synchronization alterations in resting-state fMRI.

ABSTRACT:

Background

Resting-state fMRI studies in postpartum depression (PPD) have reported voxel-wise alterations in measures of neural amplitude and synchronization, yet scarce meta-analysis has quantitatively synthesized these findings. We performed a coordinate-based meta-analysis to identify convergent amplitude and synchronization dysfunction in PPD.

Methods

We conducted a comprehensive search for whole-brain voxel-wise resting-state fMRI studies comparing PPD patients with healthy postpartum controls that reported local amplitude or synchronization metrics. Peak coordinates were analyzed using the Anisotropic effect size-signed differential mapping to delineate whole-brain functional alterations.

Results

Ten studies (288 PPD patients, 279 controls) contributed 62 peak f

SUBMITTER: Qiu J 

PROVIDER: S-EPMC12540480 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature