Long-term effectiveness of thymectomy in late-onset myasthenia gravis.

ABSTRACT:

Background

Thymectomy is a well-established treatment in anti-AChR generalized myasthenia gravis (gMG) patients aged 18-50 years. However, the MGTX trial failed to prove an additional benefit of thymectomy in late-onset MG (LOMG) patients and studies conducted so far have shown controversial results. The primary aim of this study was to assess the safety and effectiveness of thymectomy in LOMG patients compared to medical therapy alone.

Methods

This was an observational retrospective case-control study of LOMG patients followed at the MG Clinic of Pisa University Hospital from 1996 to 2024. Inclusion criteria were: diagnosis of non-thymomatous gMG with anti-AChR antibodies; age at onset ≥ 50 years, and minimum follow-up of 12 months. The cumulative incidence of disease remis

SUBMITTER: Latini E 

PROVIDER: S-EPMC12540559 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature