Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function.

ABSTRACT:

Background

Patients with severe aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF) can be distinguished into high- (HG) and low-gradient (LG) subgroups. However, less is known about their characteristics and underlying (pathophysiological) hemodynamic mechanisms.

Methods

98 AS patients with reduced LVEF were included. Subgroup characteristics were analyzed by a multimodal approach using clinical and histological data, next-generation sequencing (NGS) and applying echocardiography as well as cardiovascular magnetic resonance (CMR) imaging. Biopsy samples were analyzed with respect to fibrosis and mRNA expression profiles.

Results

40 patients were classified as HG-AS and 58 patients as LG-AS. Severity of AS was comparable between the subgroups. C

SUBMITTER: Gersch S 

PROVIDER: S-EPMC12540571 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature