Sensing the Reducing Power to Determine the Cell Fate: Flavin Redox-Switches in Signal Transduction.

ABSTRACT: Balancing electron donors and acceptors is crucial for bacterial cell to control both anabolism and catabolism rates and to keep at minimum ROS production and the resulting oxidative stress. Efficiency of nutrients uptake and assimilation is therefore linked to the availability of electron acceptors, to finally re-cycle reduced intracellular electron shuttles belonging to catabolism via respiratory chain. In case of excess reduced electron shuttles (named high reducing power), partially reduced respiratory complexes can be populated, which in turn produce ROS and oxidative stress. This is particularly relevant in the biofilm structure, where the stratified community copes with variable environment characterized by nutrients and oxygen gradients; shortage of electron acceptors found in the

SUBMITTER: Scribani-Rossi C 

PROVIDER: S-EPMC12540587 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature