Effects of antifibrotic agent Nintedanib on experimentally generated priapism model in rats.

ABSTRACT:

Purpose

This study investigated the effects of Nintedanib, a triple tyrosine kinase inhibitor, on cavernosal tissues in a rat model of ischemic priapism (IP), focusing on fibrosis and erectile function.

Methods

Sixty male Wistar Albino rats were divided into five groups (n = 12): Group 1 (control), Group 2 (1-hour IP + penectomy), Group 3 (1-hour IP + 6-week follow-up), Group 4 (1-hour IP + Nintedanib treatment for 6 weeks), and Group 5 (Nintedanib only). Erectile function was evaluated via intracavernosal pressure (ICP) during nerve stimulation. Fibrosis was assessed using Masson's trichrome staining and immunohistochemistry for VEGFR-2, PDGFR-β, and FGF-1. Oxidative stress markers (MDA, GSH, SOD) and growth factors were analyzed via ELISA and spectrophotometry. Statistical

SUBMITTER: Ceker G 

PROVIDER: S-EPMC12540617 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature