Computational insights into harmala alkaloids as novel antimalarial candidates against Plasmodium falciparum.

ABSTRACT: Malaria, caused by the Plasmodium falciparum, remains a significant global health challenge, accounting for approximately 50% of all cases and posing the greatest threat. Despite advances in control measures, malaria continues to cause an estimated one million deaths annually. The complex lifecycle of P. falciparum, involving both vertebrate hosts and anopheline mosquitoes, complicates eradication efforts. The parasite's resistance to existing antimalarial drugs, along with medication toxicity, necessitates innovative therapeutic approaches. Recent research has revealed that harmane, an alkaloid produced by an endophytic gut bacterium of anopheline mosquitoes, Delftia tsuruhatensis TC1, can impede the transmission of the malarial parasite to humans by inhibiting a crucial life stage. This

SUBMITTER: Dipto KZ 

PROVIDER: S-EPMC12540670 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature