Conformational switch upon substrate binding informs the rational design of CCoAOMT enzymes.

ABSTRACT: Poplar is a deciduous tree belonging to the willow family, whose wood has the characteristics of light texture and toughness. It can be used to produce pulp, and is one of the main raw materials in the paper industry. A large amount of lignin is produced during pulping and papermaking process, where the generated waste liquid and pollutants are one of the main sources of industrial pollution. Regulating lignin content not only enables factories to process more pulp, but also greatly reduces the use of chemical reagents and the production of pollutants. Caffeoyl coenzyme A O-methyltransferase (CCoAOMT) is a class of S-adenosyl methionine (SAM) methyltransferases, which can effectively regulate the total amount of lignin biosynthesis. At present, molecular recognition mechanism of CCoAoMT wi

SUBMITTER: Cao Y 

PROVIDER: S-EPMC12540674 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature