Biological evaluation and molecular Docking studies of the prepared chalcone derivatives as potential anti-Alzheimer agents.

ABSTRACT: Alzheimer's disease (AD) is a neurological disorder characterized by memory loss, language difficulties, and the loss of planning and coordination skills. Research done by neurologists suggest that the decline in acetylcholine and the accumulation of pathological forms of amyloid beta plaques produced by both the β- and γ-secretase enzymes in the brain as some of the primary causes of AD. Due to the multifactorial pathway associated with the progression of the disease, the inhibition of cholinesterase, β-secretase and other anti-inflammatory related enzymes have been reported as one of the major approaches in curbing the symptoms associated with it. Organic compounds containing the chalcone, sulfonyl, and allyl frameworks have been reported to possess cholinesterase, β-secretase, cyclooxyg

SUBMITTER: Agbo EN 

PROVIDER: S-EPMC12540677 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature