Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway.

ABSTRACT: Paroxetine (PRX) is widely prescribed for treating psychiatric disorders. Emerging evidence suggests that PRX can act as an immunosuppressive agent, yet the molecular mechanisms underlying its effects are not fully understood. This study has investigated whether PRX influences phenotypic changes of monocytic cells and signaling pathways induced by immune oxysterol, like 27-hydroxycholesterol (27OHChol), that triggers an inflammatory response using THP-1 monocytic cells. Treatment with PRX impaired 27OHChol-induced transcription and production of the pro-inflammatory chemokine CCL2, which was associated with decreased migration of monocytic cells, and repressed the expression and activity of MMP-9. It reduced the expression of mature dendritic cell markers, like CD80, CD83, and CD88, and pa

SUBMITTER: Park D 

PROVIDER: S-EPMC12540679 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature