Predictive value of PD-1⁺CD3⁺ T cells for 30-day mortality in patients with sepsis.

ABSTRACT: Increased expression of programmed cell death protein-1 (PD-1) on T lymphocyte subsets is associated with sepsis immunosuppression and offers potential biomarkers for prognosis. However, few studies have assessed the effect of PD-1 expression on CD3⁺ T lymphocytes in predicting sepsis. The aim of this study was to investigate the relationship between PD-1 expression on CD3⁺ T lymphocytes and 30-day mortality in patients with sepsis. A total of 180 patients with sepsis, comprising 117 survivors and 63 non-survivors, were included in the analysis. Lymphocyte counts and PD-1 expression on T lymphocytes were quantified in peripheral blood samples through the application of flow cytometry. Regression models, receiver-operating characteristic curves (ROC) and reclassificati

SUBMITTER: Wang B 

PROVIDER: S-EPMC12540681 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature