NCOA7 inhibits renal cancer progression by inducing autophagy and lipid metabolism through V-ATPase interaction.

ABSTRACT: Clear cell renal cell carcinoma is the predominant pathological subtype of renal cell carcinoma, characterized by abnormal lipid metabolism. This study aimed to investigate the role of nuclear receptor co-activator 7 (NCOA7)-mediated autophagy in lipid metabolism in renal cancer and its effects on renal cancer progression. To this end, bioinformatic analysis was performed to analyze the prognostic significance of NCOA7 in renal cancer. Immunohistochemical staining and protein blotting were used to assess NCOA7 expression levels in clinical samples. Various assays, including scratch, Transwell, colony formation, and Oil Red O staining, were used to observe the effects of NCOA7 on the biological behavior and lipid metabolism of renal cancer cells. The interaction between NCOA7 and V-ATPase w

SUBMITTER: Wang J 

PROVIDER: S-EPMC12540685 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature