JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability.

ABSTRACT: c-Jun N-terminal kinase (JNK) plays a major role in the regulation of cell death. Numerous studies have highlighted how the dynamics of this kinase dictate whether cells survive in response to cellular stress or induce cell death mechanisms. However, it remains less clear how these dynamics potentially contribute to downstream gene expression patterns through regulated transcription factors like c-Jun. To investigate this question, we used a treatment strategy with the JNK agonist anisomycin to drive specific temporal dynamics of JNK activation: sustained, transient, or pulsed activation, and assessed the impact on downstream gene expression patterns. We observed that multiple gene expression patterns emerged depending on the temporal dynamics of JNK activation. Ordinary differential equat

SUBMITTER: Jedariforoughi A 

PROVIDER: S-EPMC12540708 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature