Peripheral immune cell-specific genes in Parkinson's disease uncovered by multi-omics with therapeutic implications.

ABSTRACT: Parkinson's disease (PD) is a complex neurodegenerative disorder with growing evidence suggests peripheral immunity plays a role in its pathogenesis. However, the specific peripheral immune cell types and gene expression profiles associated with PD remain unclear. In this study, we integrated single-cell expression quantitative trait loci (sc-eQTL) data from 14 immune cell types in the OneK1K cohort with large-scale genome-wide association study (GWAS) data for PD. Using Mendelian randomization (MR) and Bayesian colocalization analyses, we identified 28 immune-cell-specific eGenes with significant associations to PD risk, among which 24 showed strong or moderate evidence of shared genetic signals. Notable candidates included FDFT1, ARSA, CTSB, and HLA-DQA1, each displaying cell-type-specif

SUBMITTER: Hong Y 

PROVIDER: S-EPMC12540756 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature