Plasmid-mediated quinolone resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from hospitalized patients, hospital environment and wastewaters in Cameroon.

ABSTRACT: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) and Klebsiella pneumoniae (ESBL-Kp) are among the leading causes of hospital-acquired infections globally. Fluoroquinolone-resistant ESBL-Ec/Kp infections have limited therapeutic options. This study investigated the prevalence and antibiotic resistance patterns of ESBL-Ec/Kp isolated from hospitalized patients, hospital environments, and wastewaters in Yaoundé, Cameroon. It further characterized ESBL genes and clonal relatedness in all ESBL-Ec/Kp isolates and assessed plasmid-mediated quinolone resistance (PMQR) genes specifically in ciprofloxacin-resistant isolates. A cross-sectional study was conducted from February to June 2024 in two healthcare facilities in Yaoundé, Cameroon. Clinical, inanimate surfaces, and wastewat

SUBMITTER: Koudoum PL 

PROVIDER: S-EPMC12540776 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature