Risk factors for unnatural mortality in persons with serious mental illness.

ABSTRACT: Rates of unnatural death in persons with serious mental illness greatly exceed those in the general population. These deaths largely result from suicides and accidents and are potentially preventable. There have been few prospective studies which have characterized clinical and biological risk factors for unnatural mortality in this population. A cohort of 1517 individuals with schizophrenia, bipolar disorder, or major depressive disorder was assessed at baseline. Unnatural cause mortality was determined from the US National Death Index with up to 23.9 years of follow-up and encompassing 18,952 person years of observation. Clinical, demographic, and serological variables were related to unnatural mortality using least absolute shrinkage and selection operators (LASSO) and Cox proportional

SUBMITTER: Dickerson F 

PROVIDER: S-EPMC12540869 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature