Stromal collagen IV expression and risk of breast cancer death in ductal carcinoma in situ.

ABSTRACT:

Background

Current treatment for ductal carcinoma in situ (DCIS) of the breast is generic, due to lack of risk stratification tools. We investigate the correlation between expression of collagen IV in the breast and risk of dying of breast cancer. We also explore the effect of collagen IV in vitro.

Methods

Tissue microarrays from a cohort of women treated for DCIS who later died from breast cancer (n = 43) or were still alive (n = 119), were analysed for collagen IV by immunohistochemistry. Oestrogen receptor positive (ER+), triple negative and human epidermal growth factor receptor 2 amplified (HER2+) cell lines were cultured with and without collagen IV.

Results

High expression of stromal collagen IV correlated with increased odds of dying of breast cancer (OR 2.50;

SUBMITTER: Rask G 

PROVIDER: S-EPMC12540875 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature