High Rates of Antimicrobial Resistance and Emergence of High-Risk Clones in Community-Acquired Uropathogenic Escherichia coli.

ABSTRACT: Urinary tract infection (UTI) is the most common bacterial infection globally and is often treated empirically in community settings, contributing to antimicrobial resistance. Uropathogenic E. coli (UPEC) is the leading cause of community-acquired UTIs (CA-UTIs), yet data on its clinical and molecular characteristics remain limited. To investigate the clinical and microbiological features of CA-UTIs, focusing on antimicrobial resistance, phylogenetic groups, virulence genes, and clonal profiles. Randomly selected E. coli isolates from CA-UTI cases underwent antimicrobial susceptibility testing. PCR was used to detect β-lactamase genes, phylogenetic groups, and key virulence factors. MLST was used for clonal typing. Clinical and demographic data were obtained through structured interviews.

SUBMITTER: Galvao VS 

PROVIDER: S-EPMC12540921 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature