Association of repeated high serum osmolarity with cognitive function in older Japanese adults in a KOBE study subanalysis.

ABSTRACT: The relationship between serum osmolarity and cognitive function has not been fully characterized. This study aimed to examine the cross-sectional association between repeated high serum osmolarity and cognitive performance among elderly community residents. We performed a subanalysis of the Kobe Orthopedic and Biomedical Epidemiological Study, including residents aged ≥ 75 years who completed the Japanese Montreal Cognitive Assessment (MoCA-J) in 2016-2017 (n = 127), 2018-2019 (n = 71), and 2020 (n = 16). Serum osmolarity was obtained from the data in the 2012-2013 survey and in the 2016-2017 survey. MoCA-J scores were dichotomized at ≤ 22 versus > 22. Multivariate logistic regression adjusted for demographic, lifestyle including daily non-alcohol drink intake, seasonal, and clinical cova

SUBMITTER: Nishikawa T 

PROVIDER: S-EPMC12540944 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature