Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

Antipsychotic drugs are associated with various tumors, but their causal relationship with lung cancer risk remains unclear. We aimed to investigate this association using Mendelian randomization (MR) analyses.

Methods

We performed summary-data-based MR (SMR) using blood-derived expression quantitative trait loci (eQTL) and two sample-MR using single nucleotide polymorphism (SNP) of antipsychotic drug target genes. Colocalization analysis was performed with cis-eQTLs, and sensitivity analyses included the Heterogeneity in dependent instruments (HEIDI) test and Multi-SNP-based SMR.

Results

SMR showed that higher DRD4 expression was associated with lower lung cancer risk (P_SMR = 0.009; P_HEIDI >0.01; P_SMR_multi = 0.0338). Two-s

SUBMITTER: Xiang J 

PROVIDER: S-EPMC12540951 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature