A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.

ABSTRACT: Heart failure (HF) is a leading cause of mortality worldwide, characterized by structural and functional alterations that result in reduced cardiac function. During the progression of HF, cardiomyocytes undergo profound remodeling - including development of pathological hypertrophy and impaired calcium handling - which exacerbates cardiac dysfunction. Given the limited efficacy of current pharmacological treatments, there is an urgent need for novel mechanistically-orientated therapeutic strategies. Circular RNAs (circRNAs), a recently identified sub-class of non-coding RNAs, have emerged as pivotal regulators of diverse cellular processes in homeostasis and disease. We identified a significant repression of circRYR2 (mmu_circ_0000431), derived from the ryanodine receptor 2 (RYR2) locus, t

SUBMITTER: Pan W 

PROVIDER: S-EPMC12540953 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature