Mechanism of Artemisia argyi Levl.et Vant. aqueous extract in alleviating dextran sulfate sodium-induced ulcerative colitis.

ABSTRACT: This study aims to explore the effect of Artemisia argyi Levl.et Vant. (AAL) on the intestinal microbiota in UC mice and the possible mechanism of AAL in alleviating UC, providing new scientific evidence for clinical application. The chemical ingredients of AAL aqueous extract were analyzed using ultra-performance liquid chromatography Q-exactive mass spectrometry (UHPLC-QE-MS) non-target metabolomics. UC model mice were induced by 3% dextran sulfate sodium (DSS) to observe the ameliorative effect of AAL on colonic inflammation in UC mice. Mouse intestinal microbial diversity, community composition, and community function were analyzed using 16 S rRNA gene sequencing, linear discriminant analysis effect size (LEfSe), and phylogenetic investigation of communities by reconstruction of unobse

SUBMITTER: Shi L 

PROVIDER: S-EPMC12541008 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature