The regulation of placental pericyte function through transforming growth factor β-1 signalling.

ABSTRACT: In the placenta, fetal-derived pericytes wrap the villous capillaries, directly interacting with endothelial cells to orchestrate the branching angiogenesis required to meet the demands of the growing fetus. In animal models of preeclampsia (PE), there is a positive correlation between reduced αSMA-expressing pericyte coverage and reduced vascular branching. Transforming Growth Factor β-1 (TGFβ-1) signalling is critical to placental development, is altered in placental pathology and alters pericyte function in other organs. However, the factors that influence placental pericyte function are under-investigated. In the present study, we investigated the in vitro effects of TGFβ-1 signalling on the population dynamics and functional measures of isolated term human placental pericytes, includi

SUBMITTER: MacPhee CA 

PROVIDER: S-EPMC12541019 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature