Segatella exacerbates chronic heart failure via TLR4/NF-κB pathway and therapeutic potential of low-carbohydrate diet.

ABSTRACT: Chronic heart failure (CHF) is the end-stage of cardiovascular disease and is linked to intestinal dysbiosis, yet the precise microbial culprits and therapeutic targets remain unclear. Here, we show that the Gram-negative genus Segatella is selectively expanded in the gut of 152 CHF patients versus 105 matched controls, correlating with impaired cardiac function and disrupted lipid and amino-acid metabolism. Mechanistically, Segatella dose-dependently intensified doxorubicin-induced apoptosis and oxidative stress in H9c2 cardiomyocytes via TLR4/NF-κB signalling; these effects were reversed by co-culture in low-carbohydrate medium. In a doxorubicin-driven CHF rat model, Segatella gavage further reduced left-ventricular ejection fraction, aggravated fibrosis and heightened myocardial TNF-α a

SUBMITTER: Abudouwayiti A 

PROVIDER: S-EPMC12541022 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature