Implantation of a vascular access button in mice.

ABSTRACT: Vascular access presents unique challenges in experimental mice due to their small size and anatomical constraints. Achieving reliable vascular access is crucial for optimizing experimental outcomes, especially in protocols requiring serial blood sampling or repeated intravascular therapy. Although vascular access buttons (VABs) offer significant advantages, their widespread adoption has been limited by technical challenges and a lack of comprehensive validation regarding their safety, feasibility, and long-term management. To address these gaps, we conducted a comprehensive evaluation of VAB implantation in mice. The technical success rate was 90.2%, and the 28-day survival rate was 80.4%. Optimal catheter insertion lengths determined by intraoperative and autopsy findings, and computed t

SUBMITTER: Yamauchi S 

PROVIDER: S-EPMC12541028 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature