Immunological phenotype in asthma and its impact on long-term renal outcomes.

ABSTRACT: Asthma is associated with both airway and systemic inflammation as well as non-respiratory adverse outcomes. However, data regarding its impact on long-term renal outcomes is lacking. We classified all asthma patients who were followed at Queen Mary Hospital in 2017 into eosinophilic or non-eosinophilic phenotypes based on their highest blood eosinophil counts (BEC) during stable state in the year (≥ 300 or < 300 cells/mm³ respectively) and prospectively evaluated their clinical outcomes in the subsequent 5 years. The relationship between patient phenotypes and the long-term renal outcomes were assessed. Five hundred and four asthma patients with baseline Stage 1 to 3 chronic kidney disease were included [296 (58.7%) and 208 (41.3%) in eosinophilic and non-eosinophilic groups re

SUBMITTER: Kwok WC 

PROVIDER: S-EPMC12541048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature