Transcriptomic dynamics of cardiac remodeling after myocardial infarction.

ABSTRACT: Myocardial infarction (MI) initiates a cascade of biological changes ending in cardiac remodeling and heart failure. Recent studies have characterized transcriptional programs in post-infarct remodeling, focusing on discrete timepoints. This study adopted a complementary approach by constructing a temporal map of gene expression changes from minutes to weeks post-myocardial infarction. Two mouse RNA-sequencing datasets were integrated, covering post-infarction timepoints from 10 min to 28 days. Expression data were analyzed using clustering, functional enrichment, and network-based hub gene analysis to define distinct gene expression modules. Nine clusters were identified, including immune activation, extracellular matrix remodeling, mitochondrial dysfunction, and circadian rhythm disrupti

SUBMITTER: Sanjaya A 

PROVIDER: S-EPMC12541056 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature