Molecules interacting with CasL-Like 2 enhances tumor angiogenesis and progression by activating mTOR/HIF1α/VEGF pathway in kidney renal clear cell carcinoma.

ABSTRACT: Kidney renal clear cell carcinoma (KIRC), as one of the most angiogenically active urological tumors, has not yet been fully elucidated its molecular mechanisms. Molecules interacting with CasL-Like 2 (MICAL-L2), a unique oxidoreductase, is known to be involved in cytoskeletal regulation. However, its role and mechanism in tumor angiogenesis remain unclear. This study aims to reveal the specific mechanism by which MICAL-L2 regulates KIRC angiogenesis through cytoskeletal dynamics and to explore its clinical translational value and significance. Bioinformatics database analysis showed that MICAL-L2 was significantly overexpressed in various solid tumors and was closely associated with shorter overall survival in KIRC patients. Gene set enrichment analysis demonstrated that MICAL-L2 expressi

SUBMITTER: Song Y 

PROVIDER: S-EPMC12541079 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature