Understanding individual neurodegenerative progression in Parkinson's disease through normative modelling.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms (e.g., bradykinesia, tremors) and non-motor symptoms (e.g., cognitive deficits). Symptom progression varies across individuals, possibly due to differences in the spread of disease pathology. This study investigates individual-level gray matter atrophy in PD patients compared to a reference cohort, modeling neurobiological trajectories to understand symptom progression. Using normative modeling, we mapped individual deviations in gray matter atrophy in PD patients (Personalized Parkinson Project, PPP; N = 408; 42% female) against a reference model (N = 58, 836) of non-diagnosed individuals. Gray matter atrophy was defined as negative deviations from the normative model in cortical thickness and subcortical volume

SUBMITTER: Fraza C 

PROVIDER: S-EPMC12541093 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature