Sex differences in allostatic load profiles and incident dementia: The AGES-Reykjavik Study.

ABSTRACT: BackgroundAllostatic load (AL), an umbrella term for the physiological response to chronic stress, is different in women and men. AL has also been associated with all-cause dementia.ObjectiveThe current study investigates if AL clusters differently in men and women, and if these sex-based clusters are associated with all-cause dementia.MethodsThe study included individuals without dementia (n = 5343, 58% women, age range: 66-98 years) at baseline from the AGES-Reykjavik Study, a population-based cohort study. AL markers of cardiovascular, lipid, neuroendocrine, and inflammatory components were assessed at baseline. Clustering of AL markers was done using latent profile analysis in men and women separately to create sex-specific AL risk groups. Sex-specific Cox regressions on the sex-specif

SUBMITTER: Twait EL 

PROVIDER: S-EPMC12541116 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature