Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine-A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Migraine is a widespread and disabling neurological disorder, and triptans are a primary treatment for acute episodes. However, around 40% of patients are non-responsive. Genetic polymorphisms can influence drug effectiveness, and several association studies exist. This systematic review consolidates findings from etiological studies, which may provide greater certainty about their use in predicting the risk of low response to triptans.

Method

This study followed COSMOS-E guidelines and employed databases like PubMed, Web of Science, and Embase until 2023. The Newcastle-Ottawa Scale (NOS) was used to assess quality, and statistical meta-analysis was performed.

Results

A comprehensive literature search identified 1421 articles from which 30 met eligibility

SUBMITTER: Andreata VG 

PROVIDER: S-EPMC12541135 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature