Efficacy and safety of vascular-targeting agents in advanced soft tissue sarcoma: a systematic review and network meta-analysis.

ABSTRACT:

Background

Soft tissue sarcomas (STS) are rare, heterogeneous tumors with poor prognosis, often characterized by high recurrence rates and limited response to conventional chemotherapy in advanced stages. Vascular-targeting agents (VTA) have shown promising efficacy for STS in numerous clinical trials; however, the optimal agent and combination strategies remain undetermined.

Objectives

This work aims to compare the clinical efficacy and adverse events of different VTA-containing regimens for patients with STS.

Design

This study is a systematic review and network meta-analysis.

Data sources and methods

We searched PubMed, Embase, and the Cochrane Library for eligible randomized clinical trials. All trials with VTA as monotherapy or VTA-included regimens in the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12541171 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature