Sex-Specific Outcome Following Targeted Blood Pressure, Oxygenation, and Fever Control After Out-of-Hospital Cardiac Arrest.

ABSTRACT:

Background

Previous studies show higher mortality for female patients with out-of-hospital cardiac arrest (OHCA) compared to males. The BOX (Blood Pressure and Oxygenation Targets in Post Resuscitation Care) trial investigated the effects of different mean arterial pressure (MAP) targets, oxygenation levels, and durations of fever control, finding no significant differences between groups.

Objectives

The purpose of this study was to explore the association between sex and mortality rates by examining both the individual and possible interactive effects of the interventions in the BOX trial for both sexes.

Methods

This two-center, randomized trial included adult comatose OHCA patients (age ≥18 years) of presumed cardiac cause. Participants were assigned to a blinded MA

SUBMITTER: Holle SLD 

PROVIDER: S-EPMC12541223 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature