Identification of Core Senescence-Related Genes and Characterization of Comprehensive Immune Landscape in Intervertebral Disc Degeneration.

ABSTRACT:

Background

Intervertebral disc degeneration (IVDD) is a musculoskeletal degenerative disease closely associated with age and immunoreaction. However, the mechanism of senescence and immune infiltration landscape in IVDD is still unclear. Our study was aimed at investigating the pivotal senescence-related genes (SRGs) and immune cells involved in IVDD.

Methods

We downloaded expression profiles by array from the GEO database and obtained 543 human SRGs from the Human Aging Genomic Resources (HAGR). Differentially expressed gene analysis, GO, KEGG, PPI network analysis, etc., were used to identify senescence-related differentially expressed genes (SRDEGs). We then used WGCNA and machine learning algorithms to explore hub genes and validated the reliability of the results in sin

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12541284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature