Altered adult brain morphology in a mouse model of late-onset fetal growth restriction.

ABSTRACT: Late-onset fetal growth restriction (FGR) from placental insufficiency results in progressive fetal hypoxia and is often associated with poor neurodevelopmental outcomes. In response to hypoxia, fetal brain sparing physiology is activated to protect the developing brain from injury via enhancing oxygen delivery. However, this protection may not be robust, and some brain regions remain susceptible to hypoxic injury. In addition, not all injury is manifested during fetal life, and may present in infant development. Using a mouse model of late-onset FGR where gestation is extended for 24 h, equivalent to approximately 2 weeks in humans, we deployed longitudinal in vivo magnetic resonance imaging to assess structural brain development from birth to adulthood. Postterm fetuses showed sig

SUBMITTER: Tan R 

PROVIDER: S-EPMC12541470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature